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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Therapeutic angiogenesis induced by human umbilical cord tissue-derived mesenchymal stromal cells in a murine model of hindlimb ischemia

Fig. 5

UCX® upregulate the expression of Tgf-β2, Ang-2, Fgf-2 and Hgf in endothelial cells isolated from ischemic gastrocnemius muscles. UCX® or their vehicle (as a control) were administered in the ischemic gastrocnemius muscle 5 hours after HLI induction. At 70 days post-HLI, the expression of pro-angiogenic factors and their receptors was evaluated by qRT‐PCR exclusively on endothelial cells isolated from gastrocnemius muscles. Each bar represents the relative gene expression in one animal. White and grey bars represent control and UCX®-treated mice, respectively. Values were normalized to 18S to obtain relative expression levels. Results expressed as log2 fold changes between ISC and NISC samples demonstrated relative abundance of the transcripts in UCX®-treated mice; in contrast, a downregulation is observed in control mice. ISC ischemic, NISC non-ischemic

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