Fig. 6

Effect of hADSC treatment on key growth factors and inflammatory factors in the DFU tissues. a Levels of VEGF, bFGF, and TGF-β in the DFU tissues at different time points were determined by enzyme-linked immunosorbent assay (ELISA).The level of VEGF, bFGF, and TGF-β was obviously higher in the hADSC-treated group compared with the PBS-treated group on D7 but there were no significant differences on D3.The higher level of VEGF and bFGF continued to D15 after treatment. b The R&D Systems Rat Cytokine Antibody Proteome Profiler Array system was used to screen for the inflammation-related cytokines and chemokines in the DFU tissues on D3 after treatment. Quantification of cytokines and chemokines mean pixel density was analyzed by Image-Pro Plus 6.0. *P < 0.05, **P < 0.01. d days, hADSC human adipose-derived stem cell, PBS phosphate-buffered saline