Discrepancy between short-term and long-term effects of bone marrow-derived cell therapy in acute myocardial infarction: a systematic review and meta-analysis

Table 2 Subgroup analysis of left ventricular ejection fraction and infarct size at 6 months

Outcome	Subgroup		Studies	Cell-injected group	Control group	Mean difference		I² (%)
Outcome	Subgroup		Studies	participants (n)	participants (n)	IV, random (%)	95 % CI	I² (%)
LVEF	Group 1	MRI	11	358	243	0.51	−1.20, 2.23	74
		Echo or LV angiogram	14	310	283	4.02	2.65, 5.39	94
		Total	25	668	526	2.65	1.61, 3.69	92
	Group 2	Placebo procedure	9	296	195	1.86	0.54, 3.19	64
		No procedure	15	358	325	3.20	1.83, 4.56	94
		Total	24	654	520	2.63	1.59, 3.67	92
Infarct size	Group 1	MRI	5	187	116	−3.96	−10.81, 2.90	96
		Echo or LV angiogram	1	20	20	0.10	−0.09, 0.29	NA
		Total	6	207	136	−3.09	−7.19, 1.02	95
	Group 2	Placebo procedure	3	133	63	−7.93	−19.57, 3.72	97
		No procedure	3	74	73	0.55	−0.62, 1.72	31
		Total	6	207	136	−3.09	−7.19, 1.02	95

IV inverse variance, CI confidence interval, I ² inconsistency (across studies), MRI magnetic resonance imaging, LVEF left ventricular ejection fraction

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