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Table 2 Subgroup analysis of left ventricular ejection fraction and infarct size at 6 months

From: Discrepancy between short-term and long-term effects of bone marrow-derived cell therapy in acute myocardial infarction: a systematic review and meta-analysis

Outcome Subgroup Studies Cell-injected group Control group Mean difference I2 (%)
participants (n) participants (n) IV, random (%) 95 % CI
LVEF Group 1 MRI 11 358 243 0.51 −1.20, 2.23 74
Echo or LV angiogram 14 310 283 4.02 2.65, 5.39 94
Total 25 668 526 2.65 1.61, 3.69 92
Group 2 Placebo procedure 9 296 195 1.86 0.54, 3.19 64
No procedure 15 358 325 3.20 1.83, 4.56 94
Total 24 654 520 2.63 1.59, 3.67 92
Infarct size Group 1 MRI 5 187 116 −3.96 −10.81, 2.90 96
Echo or LV angiogram 1 20 20 0.10 −0.09, 0.29 NA
Total 6 207 136 −3.09 −7.19, 1.02 95
Group 2 Placebo procedure 3 133 63 −7.93 −19.57, 3.72 97
No procedure 3 74 73 0.55 −0.62, 1.72 31
Total 6 207 136 −3.09 −7.19, 1.02 95
  1. IV inverse variance, CI confidence interval, I 2 inconsistency (across studies), MRI magnetic resonance imaging, LVEF left ventricular ejection fraction