Fig. 3

Gene expression analysis for fold-change of chondrogenic markers of the articular cartilage phenotype (COL2A1, ACAN), the fibrocartilaginous phenotype (COL1A1), and the hypertrophic phenotype (COL10A1, MMP13) demonstrates varied chondrogenic responses by high-GAG and low-GAG groups of each cell type, MSCs and ACPs, during pellet culture in physioxic relative to hyperoxic conditions. Data are mean ± standard deviation of fold-change for each group (n = 6–10). Statistical significance defined as *p < 0.05 by a paired or unpaired t test where appropriate. # p < 0.05 between low and high GAG pellets. ACP articular cartilage progenitor, GAG glycosaminoglycan, MSC mesenchymal stem cell