Fig. 1

Loss of P311 resulted in altered wound healing kinetics. Superficial second-degree thermal burn wounds were created in the skin of P311 WT and P311 KO mice. a Wounds were imaged after the wounding was performed. Representative wounds are shown on days 1, 5, and 7. Dotted circles indicate the wound border. b Macroscopic quantification of the wound area. Data expressed as a fraction of the initial wound area (day 0). Error bars represent SEM, n = 8 per group, Student’s t test, *P < 0.05. c Histological quantification of the wound width (left) and the neo-epidermal length (right) was performed for the wounds on days 4 and 7. Wound width defined as the distance between one leading edge and another leading edge in the same wound. Neo-epidermal length defined as the distance from the wound margin to the leading edge on the same side of one wound. *P < 0.05 for P311 WT vs P311 KO. d Wound re-epithelialization on day 7 using HE staining. Representative images are shown. Red arrow, wound margin; green triangle, leading edge of the neo-epidermis (Color figure online)