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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Adult human pancreas-derived cells expressing stage-specific embryonic antigen 4 differentiate into Sox9-expressing and Ngn3-expressing pancreatic ducts in vivo

Fig. 5

In-vivo differentiation of SSEA-4+ cells. a Selected pure CA19-9+, CA19-9, SSEA-4+, or SSEA-4 cells were transplanted into mice and then harvested 5 weeks after transplantation. b Morphology of newly formed pancreatic ducts in tissues derived from CA19-9+ cells. b′ Magnified image from b. Lu lumen. c Dermis of the dorsal skin of mice in tissues derived from CA19-9 cells. c′ Magnified image from c. d Morphology of newly formed pancreatic ducts in tissues derived from SSEA-4+ cells. d′ Magnified image from d. e Morphology of tissues derived from mice inoculated with SSEA-4 cells. e′ Magnified image from e. f CA19-9 staining in tissue of CA19-9+ cells. f′ Magnified image from f. CA19-9-expressing cells in small undifferentiated-like pancreatic ductal cells. g CA19-9 staining in tissues of SSEA-4+ cells. g′ CA19-9-expressing cells in actively differentiating pancreatic ductal cells. h Area of newly formed pancreatic ductal cells in total tissue area for SSEA-4+ cells and CA19-9+ cells. Scale bars: bg, 50 μm; b′e′, 20 μm; f′ and g′, 10 μm. SSEA-4 stage-specific embryonic antigen 4

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