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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Adult human pancreas-derived cells expressing stage-specific embryonic antigen 4 differentiate into Sox9-expressing and Ngn3-expressing pancreatic ducts in vivo

Fig. 6

Expression of Sox9 and Ngn3 in newly formed pancreatic ductal cells. a Sox9 expression in the nuclei of newly formed pancreas ductal cells from tissues derived from SSEA-4+ cells. Scale bars: left panel, 50 μm; right panel, 10 μm. b Sox9 expression in newly formed pancreas ductal cells from tissues derived from CA19-9+ cells. Scale bars: left panel, 50 μm; right panel, 10 μm. c Percentage of Sox9+ cells in total pancreatic ductal cells from tissues derived from SSEA-4+ or CA19-9+ cells. **P = 0.0005. d Ngn3 expression in tissues derived from SSEA-4+ cells. Scale bars: left panel, 50 μm; right panel, 10 μm. e Ngn3 expression in tissues derived from CA19-9+ cells. Scale bars: left panel, 50 μm; right panel, 10 μm. f Percentage of Ngn3+ cells in total pancreatic ductal cells in tissues derived from SSEA-4+ or CA19-9+ cells. g Pdx1 expression in tissues derived from SSEA-4+ cells. h Pdx1 expression in tissues derived from CA19-9+ cells. i Ki-67 expression in newly formed pancreatic ductal cells from tissues derived from SSEA-4+ cells. j Ki-67 expression in newly formed pancreatic ductal cells from tissues derived from CA19-9+ cells. k Clusterin expression in newly formed pancreatic ductal cells from tissues derived from SSEA-4+ cells. l Clusterin expression in newly formed pancreatic ductal cells from tissues derived from CA19-9+ cells. Scale bars: gl, 50 μm. SSEA-4 stage-specific embryonic antigen 4

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