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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Involvement of hepatic macrophages in the antifibrotic effect of IGF-I-overexpressing mesenchymal stromal cells

Fig. 8

Role of macrophages in AdIGF-I-MSCs induced pro-regenerative mechanisms. PCNA (a), Brca2 (b), and Gadd45α (c) in vivo mRNA expression levels were statistically compared with/without macrophages depletion. d Representative microphotographs of PCNA immunostained sections showing changes in proliferation in liver hepatocytes at 14 days after treatments. e Statistical comparisons of number of PCNA+ cells among groups. ANOVA Tukey’s post-test, ** p < 0.01 and *** p < 0.001 vs. saline; ττ p < 0.01 and τττ p < 0.001 vs. saline + LipClod; σ p < 0.05; σσσ p < 0.001 and σσσσ p < 0.0001 vs. AdIGF-I-MSCs + LipClod. n.s nonsignificant

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Stem Cell Research & Therapy

ISSN: 1757-6512