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Fig. 9 | Stem Cell Research & Therapy

Fig. 9

From: Rapamycin regulates autophagy and cell adhesion in induced pluripotent stem cells

Fig. 9

Rapamycin regulates adherens junctions and actin cytoskeleton pathways in iPSCs. Three independent lines of iPSCs were maintained in mTeSR™ (con) or in the presence of 50 or 100 nm rapamycin for 3, 6, or 9 days. Proteins were harvested for mass spectrometry analyses. (ae) Time-course changes of protein expression (mean ± SEM, n = 3). *p < 0.05. (f) Molecular network for selected proteins whose expression was altered. Data show the network of interactions between adherens junctions and actin signaling by the STRING database. Arrows indicate upregulation or downregulation of the protein expression after rapamycin treatment. Each * represents p < 0.05 for the respective culture condition in comparison to the control iPSCs in black bar

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