Fig. 3
From: Bile acid: a potential inducer of colon cancer stem cells
DCA/LCA induction of drug exclusion in HCoEpiC. Ability of HCoEpiC cells to exclude Hoechst dye (H33342) was greatly increased following 30-day incubation with DCA or LCA (a). Likewise, the expression of ABCB1 and ABCG2 was also increased in HCoEpiC cells following 18-day exposure to 50 μM LCA (b, c). Controls contained the appropriate vehicle. Data represent the mean ± standard deviation of three separate determinations. **P < 0.01 and ***P <0.001 Statistical significance determined by t test. DCA (deoxycholic acid), LCA (lithocholic acid)