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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Comparison of a teratogenic transcriptome-based predictive test based on human embryonic versus inducible pluripotent stem cells

Fig. 4

Comparison of deregulated common developmental probe sets having at least a fivefold change in expression on day 14 for human embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs) affected by valproic acid (VPA).VPA-deregulated fold change values are plotted on x and y axes. a Upregulated (left diagram) or downregulated (right diagram) developmental genes having at least a fivefold expression change, common to 14-day differentiated hESCs (x-axis) versus the 14-day differentiated foreskin hiPSCs. b Upregulated (left diagram) or downregulated (right diagram) developmental” genes having at least a fivefold change in expression, common to 14-day differentiated hESCs (x-axis) and 14-day differentiated IMR90 hiPSCs (y-axis). c Upregulated (left diagram) or downregulated (right diagram) developmental genes having at least a fivefold change in expression common to 14-day differentiated foreskin hiPSCs (x-axis) and 14-day differentiated IMR90 hiPSCs

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