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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: The lncRNAs involved in mouse airway allergic inflammation following induced pluripotent stem cell-mesenchymal stem cell treatment

Fig. 3

lncRNAs and mRNAs that were expressed in the same manner in vivo and in vitro were selected. a A Volcano plot provided the fold-change and p values of differentially expressed long noncoding RNAs (lncRNAs; top) and mRNAs (bottom). The vertical lines represent a twofold change in expression (up or down), and the horizontal lines represent p values = 0.05. Pairwise comparisons between the OVA/OVA/PBS group and PBS/PBS/PBS group (left) and between the OVA/OVA/PBS group and OVA/OVA/iPSC-MSC group (right) are shown. The red points represent differentially expressed lncRNAs or mRNAs with statistical significance (n = 3). b A Volcano plot provided fold-change and p values of differentially expressed lncRNAs (top) and mRNAs (bottom) between the memory T (Tm) + OVA group and Tm + OVA + iPSC-MSC group (n = 3). c–f Venn diagrams provided a detailed distribution of differentially expressed lncRNAs (c, d) and mRNAs (e, f) in two patterns (up then down in vivo and down in vitro (c, e), down then up in vivo and up in vitro (d, f)). The three pies represent differentially expressed lncRNAs and mRNAs of different combinations between the OVA/OVA/PBS group and PBS/PBS/PBS group (blue), between the OVA/OVA/iPSC-MSC group and OVA/OVA/PBS group (yellow), and between the Tm + OVA group and Tm + OVA + iPSC-MSC group (green). The overlap of the three pies was selected. PBS phosphate-buffered saline, iPSC-MSC induced pluripotent stem cell-mesenchymal stem cell, OVA ovalbumin

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