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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Synergistic antibacterial effect of co-administering adipose-derived mesenchymal stromal cells and Ophiophagus hannah l-amino acid oxidase in a mouse model of methicillin-resistant Staphylococcus aureus-infected wounds

Fig. 8

Proposed mechanism of synergistic antibacterial activity by combinational therapy of Oh-LAAO and mCRAMP. In the attachment phase, the treatment components, Oh-LAAO and mCRAMP, recognize and bind to the surface of MRSA. During the reaction phase, Oh-LAAO catalyses the oxidative deamination of l-amino acids into its corresponding keto acids with the release of hydrogen peroxide as a by-product, while mCRAMP reacts with the bacterial surface membrane leading to pore formation. Finally, in the entry phase the generated hydrogen peroxide enters the bacterial cells via mCRAMP-formed pores, leading to disruption of multiple intracellular component targets including proteins and DNA, subsequently causing more rapid cell lysis

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Stem Cell Research & Therapy

ISSN: 1757-6512