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Table 1 Wound area assessment at days 3 and 7 of in vivo study and histopathological scores of healing parameters performed on biopsy samples sectioned and stained by hematoxylin and eosin and Masson’s trichrome

From: Synergistic antibacterial effect of co-administering adipose-derived mesenchymal stromal cells and Ophiophagus hannah l-amino acid oxidase in a mouse model of methicillin-resistant Staphylococcus aureus-infected wounds

   % Wound area
Treatment Histological score Day 3 Day 7
MRSA-infected
 MSCs and Oh-LAAO 9.8 ± 0.6 65.8 ± 3.8 43.3 ± 3.2
 MSCs 6.1 ± 0.5 82.1 ± 2.1 57.8 ± 2.2
 Oh-LAAO 5.7 ± 0.3 83.9 ± 2.3 58.9 ± 2.1
 FAO 6.4 ± 0.3 75.5 ± 2.5 51.9 ± 2.1
 PBS 3.7 ± 0.4 91.3 ± 2.9 65.3 ± 3.1
Uninfected
 MSCs and Oh-LAAO 11.3 ± 0.5 58.9 ± 3.8 40.1 ± 3.2
 MSCs 11.5 ± 0.3 55.6 ± 3.9 38.9 ± 4.2
 Oh-LAAO 6.6 ± 0.7 74.1 ± 4.8 51.5 ± 3.9
 FAO 6.7 ± 0.5 73.3 ± 4.5 50.9 ± 3.7
 PBS 6.9 ± 0.4 71.8 ± 4.7 50.3 ± 3.5
  1. FAO Fusidic acid ointment, MSCs mesenchymal stromal cells, Oh-LAAO Ophiophagus hannah l-amino acid oxidase, PBS phosphate-buffered saline