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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Study of the reparative effects of menstrual-derived stem cells on premature ovarian failure in mice

Fig. 6

Restorative effects of MenSCs in POF are mediated via FGF2. a Relative mRNA expression levels of cytokines in MenSCs. b Cells transfected with the FGF2 siRNA expressed significantly lower levels of FGF2, as shown by ELISA (data expressed as mean ± SEM, *P < 0.05). c Comparison of serum levels of E2 between DMEM/F12-treated, NCT-CM-treated, and si-FGF2-CM-treated mice after 7 days. d Comparison of FSH levels in DMEM/F12-treated, NTC-CM-treated, and si-FGF2-CM-treated mice after 7 days (data expressed as mean ± SEM, *P < 0.05). e Representative images showing H&E staining after 7 days. Lesions were more pronounced in the ovaries of si-FGF2-CM-injected mice than in mice treated with NTC-CM. Scale bars: 100 μm. CM conditioned media, E2 oestradiol, FGF2 fibroblast growth factor 2, FSH follicle-stimulating hormone, NTC negative transfection control siRNAs, IGF-1insulin-like growth factor-1, VEGF vascular endothelial growth factor, HGF hepatocyte growth factor), FGF2fibroblast growth factor 2, CSF colony stimulating factor

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