Fig. 1

Human umbilical cord-derived mesenchymal stem cell exosomes (hucMSC-Ex) prevent deterioration of renal function in vivo. a Representative images of renal histology (200×, scale bar = 50 μm). b The histomorphological score. c Immunohistochemical analysis of PCNA expression in kidney tissues (200×, scale bar = 50 μm). d Percentage of proliferating cell nuclear antigen (PCNA)-positive cells. e TUNEL assay for apoptotic cells in rat renal tissues (200×, scale bar = 50 μm). f Percentage of apoptotic cells. Serum creatinine (Cr) (g) and blood urea nitrogen (BUN) (h) levels were measured at different times after cisplatin injection. Data are expressed as mean ± SD. *P < 0.05, n = 6. Rats treated as mentioned for the in vivo rat model were divided into four groups as follows: 1) control; 2) phosphate-buffered saline (PBS); 3) hucMSC-Ex; and 4) human fetal lung fibroblast-1exosomes (HFL1-Ex). All animals were sacrificed at 3 days after cisplatin injection