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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Pre-incubation with hucMSC-exosomes prevents cisplatin-induced nephrotoxicity by activating autophagy

Fig. 6

A proposed model for the mechanism of human umbilical cord-derived mesenchymal stem cell exosome (hucMSC-Ex)-mediated protection against cisplatin-induced AKI. hucMSC-Ex activates autophagy and leads to the reduction in cell apoptosis and inflammatory responses, and the improvement of renal recovery. 3MA 3-methyladenine, IL interleukin, mTOR mammalian target of rapamycin, Rapa rapamycin, TNF tumor necrosis factor

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Stem Cell Research & Therapy

ISSN: 1757-6512