Fig. 4

Comparison of the cardiac regeneration potential of manually and automatically isolated CD133⁺ stem cells. 1 × 10⁵ CD133⁺ stem cells were intramyocardially transplanted into SCID bg mice after myocardial infarction (MI). Ejection fraction (EF) (a), velocity of pressure rise (dPdt_max) (b), end-diastolic volume (EDV) (c), and end-systolic volume (ESV) (d) were assessed by pressure-volume (PV) loop measurements 3 weeks after cell transplantation. For control untreated infarction (MIC) and SHAM operation were used. All parameters were measured under baseline and under stress conditions mediated by intravenous dobutamine administration (10 μg/kg/min). Data are presented as mean ± SEM. *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001 vs. MIC; ns not significant