Fig. 4

Donor MSCs persist and proliferate in the liver of 70% hepatectomized mice. Normal and obese mice received 5 × 10⁵ MSCs^GPF post-Hpx. Two, 10 and 30 days later, the presence of donor cells was evaluated by GFP immunoreactivity (Alexa Fluor 488 – green), nuclei were counterstained with DAPI (blue). a Representative micrographs of donor MSCs^GFP in the liver parenchyma. MSC proliferation in hepatic tissue was evaluated by PCNA immunoreactivity (Alexa Fluor 555 – red). b Representative micrographs of MSCs^GFP proliferation 30 days after their administration