Human umbilical cord-derived mesenchymal stromal cells protect against premature renal senescence resulting from oxidative stress in rats with acute kidney injury

Table 1 Renal function on day 2 after ischaemia/reperfusion

Parameter	Control	IRI	IRI + huMSC
Urea (mg/dl)	52 ± 2.5	234 ± 36.3^a,b	108 ± 19.6
Creatinine (mg/dl)	0.3 ± 0.02	2.4 ± 0.4^a,b	0.9 ± 0.17
Creatinine clearance (ml/min/100 g BW)	0.59 ± 0.04	0.10 ± 0.02^a,b	0.23 ± 0.05^a
FENa (%)	0.10 ± 0.01	3.27 ± 1.10^a,b	0.48 ± 0.09
Urinary flow rate (ml/min/100 g BW)	0.002 ± 0.0004	0.005 ± 0.0006^a	0.006 ± 0.0007^a

IRI ischaemia/reperfusion injury (rats submitted to renal artery clamping for 45 min, followed by 6 h of reperfusion), IRI + huMSC IRI + human umbilical cord-derived mesenchymal stromal cells (rats submitted to IRI and subsequently treated with huMSCs), BW body weight, FENa fractional excretion of sodium
^a p < 0.05 vs control
^b p < 0.05 vs IRI + huMSC

ISSN: 1757-6512