Skip to main content
Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Metformin promotes the survival of transplanted cardiosphere-derived cells thereby enhancing their therapeutic effect against myocardial infarction

Fig. 2

Combination of metformin (MET) treatment and cardiosphere-derived cell (CDC) transplantation improved cardiac function in myocardial infarction (MI) mice. a Representative echocardiographic images of hearts with different treatments at 4 weeks post-MI. Scale bar = 2 mm. b Heart rates were controlled to be similar in different groups. c,d Left ventricular ejection fraction and fraction shortening at 4 weeks post-MI. n = 8. Data were analyzed by one-way ANOVA with post-hoc comparisons by the Tukey’s test. *P < 0.05 vs. sham; # P < 0.05 vs. MI + phosphate-buffered saline (PBS); &P < 0.05 vs. MI + MET; % P < 0.05 vs. MI + CDC. MET/CDC MET-pretreated CDCs

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512