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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Metformin promotes the survival of transplanted cardiosphere-derived cells thereby enhancing their therapeutic effect against myocardial infarction

Fig. 4

Metformin (MET) treatment increased cardiosphere-derived cell (CDC) survival after transplantation into post-myocardial infarction (MI) hearts. a Representative images of survived CDCs in hearts at 7 days after transplantation. Heart tissue was immunostained for tropomyosin (red), green fluorescent protein (GFP) (green) and DAPI (blue). Scale bar = 100 μm. b Post-MI hearts with CDC transplantation were enzymatically digested, and small cells from the heart (<30 μm diameter) were collected after depletion of cardiomyocytes. As indicated with the white arrows, GFP-positive cells represent surviving CDCs under fluorescence microscope. Scale bar = 50 μm. c The percentage of surviving CDCs out of the total transplanted CDCs at 7 days post-transplantation. n = 5. Data were analyzed by one-way ANOVA with post-hoc comparisons by the Tukey’s test. *P < 0.05 vs. MI + CDC. MET/CDC MET-pretreated CDC

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Stem Cell Research & Therapy

ISSN: 1757-6512