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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: The effects of glomerular and tubular renal progenitors and derived extracellular vesicles on recovery from acute kidney injury

Fig. 2

Effect of different renal stem/progenitor cells and their derived EVs in IRI mice: renal morphology. a The number of hyaline casts and b tubular necrosis (TN) observed under high power field (HPF: ×40) is expressed as mean ± SD. An ANOVA with Dunnett’s multiple comparison test was performed, (* p < 0.05). c Representative micrographs of renal histology of: IRI mice injected with different treatments and sham-operated SCID mice. Original magnification: ×20. In the representative image related to IRI-CTL intratubular hyaline cast (black arrow) and a tubule with signs of necrosis (epithelial cell denudation and presence of intratubular cell debris) (white arrow) can be observed. IRI-CTL mice injected with vehicle alone, IRI-Gl-MSC mice injected with GI-MSC, IRI-Gl-MSC-EV EVs produced by Gl-MSCs, IRI-Gl-MSC-EV-float EVs produced by Gl-MSCs and obtained by floating process, IRI-RNase-Gl-MSC-EV EVs produced by Gl-MSCs and treated with RNase, IRI-T-CD133 + T-CD133+ cells, IRI-T-CD133 + -EV EVs produced by T-CD133+, IRI-F-EV EVs derived from fibroblasts

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