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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Let-7a-transfected mesenchymal stem cells ameliorate monocrotaline-induced pulmonary hypertension by suppressing pulmonary artery smooth muscle cell growth through STAT3-BMPR2 signaling

Fig. 2

Expression of let-7a in MSCs and PAH rats. Rats were injected with MCT (60 mg/kg) for 2 weeks to induce the PAH model. Then, PBS and MSCs were injected into rats with PAH. The expression of let-7a was analyzed by quantitative RT-PCR (a). MSCs were exposed to hypoxia (3% oxygen) or normoxia (control group) for 24 h. The expression of let-7a was detected in control and hypoxia-treated groups (b). To explore the effects of MSC-based therapy against PAH, MSCs were exposed to Ad-let-7a or Ad-NC viruses and cultured for 48 h. Then, quantitative RT-PCR was performed to detect let-7a expression in MSCs (c). *p < 0.05

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