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Table 1 Studies that have evaluated the association between age and human ADSC and adipocyte functionality (ordered by sample size)

From: Systematic review of patient factors affecting adipose stem cell viability and function: implications for regenerative therapy

Reference LOE Sample size (n) Subjects F (n or %) Age (years; mean ± SD or only mean) Age (years) (subset categories) Outcome: ADSC yield Outcome: differentiation potential
van Harmelan et al. 2003 [34] 2 189 Elective breast reduction procedure 100% 16–73 - No significant correlation between age and ADSCs per gram of tissue No significant correlation between age and ADSC differentiation
Faustini et al. 2010 [29] 2 125 Donor sites varied by gender. Men had more resected samples; women had more lipoaspirates 70% 15–87 (51.31) - No significant correlation between age and ADSC yield (stratified by gender) -
Yu et al. 2010 [36] 2 64 Elective liposuction surgery or abdominoplasty 90.6% 18–66 (43.6 ± 11.1) - No significant correlation between age and ADSC yield -
Madonna et al. 2011 [42] 2 52 Patients undergoing abdominal surgery with varying cardiovascular history 38% 68 ± 13 40–54 (12)
55–65 (18)
66–92 (22)
Significant negative correlation between age and ADSC yield (subset matched for co-morbidities)  
Harris et al. 2010 [30] 2 50 Lipoaspirate from abdomen in patients undergoing elective vascular procedures Multiple co-morbidities 36% 59 ± 16 <70 (35)
>70 (15)
No significant correlation between age and ADSC yield No significant correlation between ADSC differentiation and age
Alt et al. 2012 [38] 2 40 Adipose tissue from healthy donor tissue - 15–71 <20 (15)
30–40 (17)
 > 50 (8)
Significant negative correlation between age and ADSC yield Significant negative correlation between age and ADSC proliferation and differentiation rate
Mojallal et al. 2011 [31] 2 42 Elective liposuction—abdomen 100% 27–71 - No significant correlation between age and ADSC yield and proliferation -
Choudhery et al. 2014 [37] 2 29 Lipoaspirate from healthy men and women 69% 24–67 <30 (8)
35–50 (10)
 > 60 (11)
Significant negative correlation between donor age and ADSC yield Significant negative correlation between age and ADSC proliferation rate Adipogenic differentiation was independent of age
Osteogenic and chondrogenic potential decreased with age
Hauner et al. 1989 [121] 2 27 Subcutaneous tissue from patients undergoing elective abdominal surgery 37% 20–83 - Significant negative correlation between age and ADSC yield (in both genders) Significant negative correlation between age and ADSC proliferation (in both genders)
de Girolamo et al. 2009 [122] 2 26 Lipoaspirate from healthy women 100% 21–68 <35 (12) 
> 45 (14)
Significant positive correlation between age and ADSC yield Proliferation rates higher in younger women but not statistically significant No significant impact of age on adipogenic differentiation potential
Significant negative correlation of age with osteogenic potential
Padoin et al. 2008 [32] 2 25 Elective liposuction—multiple donor sites 100% 21–37 (30.7 ± 4.3) - No significant correlation between age and ADSC yield -
Geissler et al. 2014 [27] 2 24 Lipoaspirate from healthy women. Multiple donor sites 100% 25–71 (51) ≤45 (9)
 ≥ 46 (15)
Analyses stratified by donor site: Abdomen: younger women showed significantly higher yield Flanks: older women had significantly higher ADSC yield -
Aust et al. 2004 [28] 2 18 Elective liposuction 87.5% 20.5–29.3 (24.9 ± 2.7) - No significant correlation between age and ADSC yield -
Schipper et al. 2008 [33] 2 12 Lipoaspirate from body-contouring surgery in previously obese patients 100% 25–60 25–30 (3)
40–45 (4)
55–60 (5)
  Higher proliferation of ADSC and lower susceptibility to apoptosis in 20 year old group (not statistically significant)
Yoshimura et al. 2006 [35] 2 - - 100% 21–59 - No significant correlation between ADSC yield and age -
Zhu et al. 2009 [43] 2 - Lipoaspirate from multiple donor sites 100% 20–58 - - Slower rate of proliferation with increasing age (not statistically significant) Significant decrease in osteogenic potential
  1. ADSC adipocyte-derived stem cell, F female, LOE Level of Evidence, n number, SD standard deviation