Fig. 2

The interaction network of significant pathways (Path-net). The role of each pathway in the network was measured by counting its connections to upstream and downstream pathways. A pathway with a high degree implied that it played an important role in the signaling network. Blue represents downregulated pathways, red represents upregulated pathways, and yellow represents up- and downregulated pathways. The lines indicate interactions between pathways. ECM extracellular matrix, TGF transforming growth factor