Fig. 9

Blocking CTLA-4 reduces the ability of CD4⁺CD117⁺CD44⁺ cells to suppress T-cell proliferation. a a T cells only; b T cells + anti-CD3 + IL-2; c CD44⁺CD117^– T cells + anti-CD3 + IL-2; d CD44⁺CD117⁺ T cells + anti-CD3 + IL-2 + Isotype Armenian Hamster IgG; e (CD44⁺CD117⁺ T cells + CTLA-4 broke) + anti-CD3 + IL-2 + T cells; f CD44⁺CD117⁺ T cells cultured with T cells in a Transwell plate. B Data pooled from three independent experiments representing mean percent of totals ± SD. ***p < 0.001