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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Human amnion epithelial cells rescue cell death via immunomodulation of microglia in a mouse model of perinatal brain injury

Fig. 5

Assessment of the microglial response in the striatum. Representative images illustrating Iba1 immunoreactivity in the cingulum of control (a), LPS + hyperoxia (b) and LPS + hyperoxia + hAEC (c) animals. d Density of Iba1-positive cells in the striatum was not different between control and LPS + hyperoxia animals but was increased with administration of hAECs. eg Assessment of the microglial response in the cerebral cortex. Density of Iba1-positive cells was not different between control and LPS + hyperoxia animals in all three bins, but was increased with administration of hAECs in bin 1 (e) and bin 2 (f). hj Assessment of the microglial response in the white matter tracts. Density of Iba1-positive cells was not different between control and LPS + hyperoxia animals in the corpus callosum (h) but was reduced in the cingulum (i) and external capsule (j).*p < 0.05; **p < 0.01; †LPS + hyperoxia versus control, p < 0.05. Scale bar (a–c) = 200 μm. CC corpus callosum, Cg cingulum, hAEC human amnion epithelial cell, LPS lipopolysaccharide

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