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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Knockdown of SLC41A1 magnesium transporter promotes mineralization and attenuates magnesium inhibition during osteogenesis of mesenchymal stromal cells

Fig. 5

Slc41a1 knockdown attenuated the high magnesium-induced inhibition of Wnt signaling. Gene expression of Wnt5a, β-catenin, and Dkk1 in control (ctrl) and Slc41a1 knockdown (KD) mMSCs with normal and high extracellular magnesium concentration before and 3 days after osteogenic induction (D0 and D3). Two-way analysis of variance followed by Tukey’s post-hoc tests was performed for multiple comparisons. p < 0.05 is defined statistically significant; same letters denote no significant differences. Data normalized by the gene expression of undifferentiated wild-type MSCs (D0) and presented as mean ± SEM (N = 3, n = 3)

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Stem Cell Research & Therapy

ISSN: 1757-6512