Fig. 4

The changes of fat-suppressed T2-weighted (FST2W) MRI in cell-transplanted root canal in five patients. Squares indicate the teeth with cell transplantation. a–c Twelve weeks and d–f 24 weeks after transplantation of MDPSCs and G-CSF with collagen. a,d Sagittal slice; b,e axial slice at the coronal part of the root canal; c,f axial slice at the apical part of the root canal. g The relative SI of MRI. There are significant differences in the relative SI between pulpectomized root canal and cell transplanted root canal at 12 and 24 weeks both in the coronal part and apical part (**P < 0.01); data are expressed as mean ± SD (n = 3). There is a significant difference in the relative SI of root canal between 12 weeks and 24 weeks in the coronal part (*P <0.05); data are expressed as mean ± SD (n = 4)