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Table 4 Safety and efficacy evaluation

From: Pulp regeneration by transplantation of dental pulp stem cells in pulpitis: a pilot clinical study

Characteristics Patient 1 Patient 2 Patient 3 Patient 4 Patient 5
Abnormality
 Blood test
 Urine test
 Cardiogram
Local clinical examination
Electric pulp test
 Day positive reaction started + Day 6 (25, 29, 31) (control right lower 2nd premolar 31) a + Day 6 (55, 58, 69) (control left upper canine 48) + Day 28 (49, 64, 80+) (control left lower 2nd premolar 24) + Day 14 (45, 62, 80+) (control right upper incisor 13)
 12 weeks + (34, 38, 36) (control left upper 2nd premolar 45) a + (43, 47, 47) (control left upper incisor 37) + (39, 44, 52) (control left lower 2nd premolar 23) + (53, 53, 59) (control right upper incisor 11)
 24 weeks + (40, 41, 44) (control left upper 2nd premolar 41) a + (43, 44, 46) (control left upper canine 25) + (50, 57, 57) (control right lower 1st premolar 24) + (43, 48, 51) (control right upper incisor 10)
MRI (relative signal intensity of apical part of root canal at 24 weeks) 0.8 0.9 0.9 0.7 0.9
X-ray (periapical radiolucency at 24 weeks) –/+b, c +
Cone beam computed tomography (lateral dentin formation) + + +
  1. MRI magnetic resonance imaging
  2. a The positive reaction was detected after 36 weeks
  3. b Area of the periapical radiolucency was gradually reduced after cell transplantation
  4. c Widening of periodontal ligament space was detected