Skip to main content

Advertisement

Table 4 Safety and efficacy evaluation

From: Pulp regeneration by transplantation of dental pulp stem cells in pulpitis: a pilot clinical study

Characteristics Patient 1 Patient 2 Patient 3 Patient 4 Patient 5
Abnormality
 Blood test
 Urine test
 Cardiogram
Local clinical examination
Electric pulp test
 Day positive reaction started +
Day 6
(25, 29, 31)
(control right lower 2nd premolar 31)
a +
Day 6
(55, 58, 69)
(control left upper canine 48)
+
Day 28
(49, 64, 80+)
(control left lower 2nd premolar 24)
+
Day 14
(45, 62, 80+)
(control right upper incisor 13)
 12 weeks +
(34, 38, 36)
(control left upper 2nd premolar 45)
a +
(43, 47, 47)
(control left upper incisor 37)
+
(39, 44, 52)
(control left lower 2nd premolar 23)
+
(53, 53, 59)
(control right upper incisor 11)
 24 weeks +
(40, 41, 44)
(control left upper 2nd premolar 41)
a +
(43, 44, 46)
(control left upper canine 25)
+
(50, 57, 57)
(control right lower 1st premolar 24)
+
(43, 48, 51)
(control right upper incisor 10)
MRI (relative signal intensity of apical part of root canal at 24 weeks) 0.8 0.9 0.9 0.7 0.9
X-ray (periapical radiolucency at 24 weeks) –/+b, c +
Cone beam computed tomography (lateral dentin formation) + + +
  1. MRI magnetic resonance imaging
  2. a The positive reaction was detected after 36 weeks
  3. b Area of the periapical radiolucency was gradually reduced after cell transplantation
  4. c Widening of periodontal ligament space was detected