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Table 4 Safety and efficacy evaluation
From: Pulp regeneration by transplantation of dental pulp stem cells in pulpitis: a pilot clinical study
| Characteristics | Patient 1 | Patient 2 | Patient 3 | Patient 4 | Patient 5 |
|---|---|---|---|---|---|
| Abnormality | |||||
| Blood test | – | – | – | – | – |
| Urine test | – | – | – | – | – |
| Cardiogram | – | – | – | – | – |
| Local clinical examination | – | – | – | – | – |
| Electric pulp test | |||||
| Day positive reaction started |
+ Day 6 (25, 29, 31) (control right lower 2nd premolar 31) | –a |
+ Day 6 (55, 58, 69) (control left upper canine 48) |
+ Day 28 (49, 64, 80+) (control left lower 2nd premolar 24) |
+ Day 14 (45, 62, 80+) (control right upper incisor 13) |
| 12 weeks |
+ (34, 38, 36) (control left upper 2nd premolar 45) | –a |
+ (43, 47, 47) (control left upper incisor 37) |
+ (39, 44, 52) (control left lower 2nd premolar 23) |
+ (53, 53, 59) (control right upper incisor 11) |
| 24 weeks |
+ (40, 41, 44) (control left upper 2nd premolar 41) | –a |
+ (43, 44, 46) (control left upper canine 25) |
+ (50, 57, 57) (control right lower 1st premolar 24) |
+ (43, 48, 51) (control right upper incisor 10) |
| MRI (relative signal intensity of apical part of root canal at 24 weeks) | 0.8 | 0.9 | 0.9 | 0.7 | 0.9 |
| X-ray (periapical radiolucency at 24 weeks) | – | –/+b, c | – | + | – |
| Cone beam computed tomography (lateral dentin formation) | + | – | – | + | + |
