Table 4 Safety and efficacy evaluation

 Blood test

–

–

–

–

–

 Urine test

–

–

–

–

–

 Cardiogram

–

–

–

–

–

Local clinical examination

–

–

–

–

–

 Day positive reaction started

+

Day 6

(25, 29, 31)

(control right lower 2nd premolar 31)

–^a

+

Day 6

(55, 58, 69)

(control left upper canine 48)

+

Day 28

(49, 64, 80+)

(control left lower 2nd premolar 24)

+

Day 14

(45, 62, 80+)

(control right upper incisor 13)

 12 weeks

+

(34, 38, 36)

(control left upper 2nd premolar 45)

–^a

+

(43, 47, 47)

(control left upper incisor 37)

+

(39, 44, 52)

(control left lower 2nd premolar 23)

+

(53, 53, 59)

(control right upper incisor 11)

 24 weeks

+

(40, 41, 44)

(control left upper 2nd premolar 41)

–^a

+

(43, 44, 46)

(control left upper canine 25)

+

(50, 57, 57)

(control right lower 1st premolar 24)

+

(43, 48, 51)

(control right upper incisor 10)

MRI (relative signal intensity of apical part of root canal at 24 weeks)

0.8

0.9

0.9

0.7

0.9

X-ray (periapical radiolucency at 24 weeks)

–

–/+^{b, c}

–

+

–

Cone beam computed tomography (lateral dentin formation)

+

–

–

+

+