Fig. 6
Effects of iMSC-Exos and SMMSC-Exos on migration and proliferation of chondrocytes. a Light microscopy images of scratch wound assays. b Quantitative analysis of migration rates at 24 and 48 h. Scratch wound assays indicated that both iMSC-Exos and SMMSC-Exos significantly enhanced the motility of chondrocytes and that iMSC-Exos were more effective than SMMSC-Exos. c iMSC-Exos and SMMSC-Exos stimulated chondrocyte proliferation in a dose-dependent manner. At the concentration of 108 exosomes/ml, iMSC-Exos showed a more powerful effect on chondrocyte proliferation than did SMMSC-Exos. *P < 0.05. iMSC-Exos exosomes secreted by induced pluripotent stem cell-derived mesenchymal stem cells, OARSI Osteoarthritis Research Society International, SMMSC-Exos exosomes secreted by synovial membrane mesenchymal stem cells