Skip to main content

Advertisement

Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Stroke alters behavior of human skin-derived neural progenitors after transplantation adjacent to neurogenic area in rat brain

Fig. 1

Stroke does not alter survival or proliferation of human skin-derived neural progenitors transplanted adjacent to SVZ. a Schematic representation of transplantation approach and injection site in relation to different structures. b-c Survival (b) and proliferation (c) of grafted cells in intact (n = 6) and stroke-subjected (MCAO; n = 7) rats at 2 months after transplantation. Data represent means ± SEM. d-e Fluorescence photomicrographs showing location of grafted cells (GFP+, green) transplanted in the intact (d) and stroke-injured (MCAO) rats (e) immunostained (in red) with human-specific marker SC101, in relation to RMS. f-g Fluorescence photomicrographs showing examples of grafted cells (GFP+, green) transplanted in the intact (f) and stroke-injured (MCAO) rats (g) co-expressing Ki67 (in red). Hoechst nuclear counterstain (in blue) is included in (f-g). h-i Fluorescence photomicrographs showing examples of grafted cells (GFP+, green) transplanted in the intact (h) and stroke-injured (MCAO) rats (i) immunostained with SC101 (in red) and co-expressing DCX (in orange). Arrows depict examples of GFP+/SC101+/DCX+ cells. Ctx cortex, LV lateral ventricle, SVZ subventricular zone, Str striatum, RMS rostral migratory stream, MOB main olfactory bulb. Scale bars represent 300 μm in (d and e), 50 μm in (f and g) and 25 μm in (h and i)

Back to article page