Fig. 3

Stroke alters migration pattern of human skin-derived neural progenitors transplanted adjacent to SVZ. a-d Fluorescence photomicrographs showing migration pattern of grafted cells (GFP+, green) 2 months after transplantation in intact (a-b) and stroke-injured (c-d) rats. Low magnification overviews (a, c) and higher magnifications of the migrating grafted cells (b, d) are presented for each condition. Note the difference in the direction of the migratory pattern of grafted cells between the groups. e-f Analysis of mean (e) and maximum (f) distances migrated by the grafted cells from the implantation site at 2 months after transplantation in intact (around 2000 cells analyzed per animal, n = 6) and stroke-injured (around 2000 cells analyzed per animal, n = 7; MCAO) rats. Data represent means ± SEM; *P < 0.05, two-tailed unpaired t test. Str striatum, RMS rostral migratory stream. Scale bars represent 500 μm in (a and c) and 100 μm in (b and d)