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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: DNA double-strand breaks in human induced pluripotent stem cell reprogramming and long-term in vitro culturing

Fig. 3

DSBs recognized by γH2AX (a,c) and p53-binding protein 1 (53BP1) (b,d) in non-irradiated control cells (Ctrl) (a,b) or 0.5 h after γ-irradiation with 1 Gy (c,d). Comparison of fibroblasts (human dermal fibroblast; hDF), hiPSCs (CBIA-3, CBIA-5, and CBIA-7) and hESCs (CCTL-14) at low or high passage number. The number of foci in each cell is visualized as a dot, and the mean value is shown as a black line for each sample. The results are shown in the EdU-negative population. *P ˂ 0.05 between hDF and iPSCs in low passage, and between low and high passages, by one-way ANOVA and Tukey’s multiple comparison test

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