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Table 2 Effects of SPIONs and static magnetic fields on mesenchymal stromal cell properties

From: Magnetic targeting as a strategy to enhance therapeutic effects of mesenchymal stromal cells

MSC origin Nanoparticle Magnetic device SMF strength (mT) Time of exposure Effects of SMFs on MSC (compared to control groups) Reference
Human bone marrow Ferucarbotran/Resovist® (60 μg/ml) Permanent magnet 600 24 hours and 12 days Reduction of colony-forming units, increased adipogenesis, and osteogenesis inhibition [31]
Human bone marrow Feridex (Tanabe Seiyaku) Electromagnet 600 1 hour Increased expression of integrins and adhesion proteins [30]
Murine bone marrow None Electromagnet 4, 7, and 15 1 to 4 days Reduction of MSC viability and proliferation rates [45]
Canine and equine adipose tissue None Permanent magnet 500 1 to 7 days Increased MSC proliferation rates in both species; increased secretion of extracellular vesicles by equine MSCs [46]
Human bone marrow None Permanent magnet 400 14 days Increased chondrogenesis [48]
Equine adipose tissue None Permanent magnet 500 1 to 7 days Ultrastructural changes; increased proliferation rate, colony-forming units, and secretion of extracellular vesicles; changes in vesicle content. [32]
Human bone marrow None Permanent magnet 3, 15, and 50 1 to 9 days Increased MSC proliferation rates; osteogenesis stimulation. [47]
Murine adipose tissue Feridex (Berlex) Permanent magnet 500 7 days Reduction of MSC viability, proliferation rates, angiogenic cytokine release, osteogenesis and adipogenesis; phenotype shift. [18]
  1. MSC mesenchymal stromal cell, SMF static magnetic field, SPION superparamagnetic iron oxide nanoparticle