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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Mesenchymal stem cells increase expression of heme oxygenase-1 leading to anti-inflammatory activity in treatment of acute liver failure

Fig. 1

Transplanted BMSCs, via HO-1, significantly improve liver function, inflammation, and survival in ALF induced by D-Gal/LPS. a Kaplan-Meyer curve showing survival over 12 days (n = 10 per group) following various treatments. BMSCs significantly decreased mortality of ALF (p < 0.05), whereas Znpp treatment blocked this protective effect (p < 0.05). Hemin also resulted in a significant decrease in mortality (p < 0.05). b Liver injury scores (n = 6 per group) were significantly decreased by BMSCs (p < 0.05); Znpp reversed this protective effect (p < 0.05). Hemin treatment resulted in a decrease in injury score (p < 0.05). c Serum ALT, AST, NH3, and TBIL (n = 10 per group). BMSCs infusion significantly decreased liver enzymes over 7 days after infusion (p < 0.05); Znpp reversed this effect (p < 0.05). Hemin treatment resulted in a significant decrease in liver function tests (p < 0.05). d Representative images of hematoxylin and eosin staining (×100/×200). Treatment groups: control, ALF, ALF followed by intravenous MSCs (ALF + MSC) 1 h post-induction, ALF followed by MSCs and Znpp (ALF + MSC + Znpp) 1 h post-induction, and ALF followed by hemin (ALF + hemin) 1 h post-induction. Data are mean ± SD. (* p < 0.05 vs. control group; $ p < 0.05 vs. ALF group; # p < 0.05 vs. ALF + MSC group). Abbreviations: ALF acute liver failure, ALT alanine aminotransferase, AST aspartate transaminase, BMSCs bone marrow-derived mesenchymal stem cells, D-Gal d-Galactosamine, HO-1 heme oxygenase-1, LPS lipopolysaccharide, NH 3 ammonia, TBIL total bilirubin, Znpp zinc protoporphyrin

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