Fig. 5

CM obtained from MenSCs improve ovarian function following chemotherapy-induced injury. a Schematic of the experimental procedure used to explore the reparative effects of CM in POF mice. b Serum E2 levels were measured in each of the three groups after 7 days. c Serum FSH levels were measured in each of the three groups after 7 days (data expressed as mean ± SEM, *P < 0.05). d Representative photomicrograph showing the results of H&E staining in each group at 7 days after injury. Scale bars = 100 μm. e Apoptosis evaluated using TUNEL staining in each group. Scale bars = 200 μm. CM conditioned media, CDDP cisplatin, DAPI 4′,6-diamidino-2-phenylindole, E2 oestradiol, FSH follicle-stimulating hormone, H&E haematoxylin and eosin, POF premature ovarian failure, TUNEL terminal deoxynucleotidyl transferase mediated dUTP nick end labelling