Skip to main content
Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Human and feline adipose-derived mesenchymal stem cells have comparable phenotype, immunomodulatory functions, and transcriptome

Fig. 2

Human and feline adipose-derived mesenchymal stem cells (ASCs) display similar proliferative capacity and immune-suppressive functions. Doubling times were calculated for feline ASCs at passages 2–6 and for human ASCs at passages 3–6. The proliferation rate of human and feline ASCs is comparable throughout multiple passages (a). Feline ASCs co-incubated with stimulated peripheral blood mononuclear cells (PBMCs) suppress lymphocyte proliferation regardless of direct contact (transwells) (b). Human ASCs similarly inhibit leucoagglutinin (PHA)-induced lymphocyte proliferation; however, direct contact with stimulated PBMCs leads to stronger inhibition than the transwell condition (c). Data presented as mean and standard error. *P < 0.05, **P < 0.01, ***P < 0.001. BrdU 5-bromo-29-deoxyuridine, ConA concanavalin A, MSC mesenchymal stem cell

Back to article page