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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Human and feline adipose-derived mesenchymal stem cells have comparable phenotype, immunomodulatory functions, and transcriptome

Fig. 3

Human and feline ASCs produce immunomodulatory mediators. Feline ASCs in the presence of proliferating peripheral blood mononuclear cells (PBMCs) increase indoleamine 2,3 dioxygenase (IDO) activity (a). Increased IDO activity was observed by stimulated human ASCs, but was not statistically significant (b). Production of prostaglandin E2 (PGE 2 ) occurred in both standard and transwell conditions in cats; however, greater production occurred when feline ASCs were in direct contact with stimulated PBMCs (c). Human ASCs produce PGE2 to the same magnitude with or without contact to stimulated PBMCs (d). Interleukin-6 (IL-6) was significantly upregulated regardless of contact for both feline (e) and human (f) ASC co-cultures. Feline ASCS produced vascular endothelial growth factor (VEGF) in standard and transwell conditions in cats (g). However, VEGF was not significantly increased above baseline by stimulated human ASCs (h). Data presented as mean and standard error. *P < 0.05, **P < 0.01, ***P < 0.001. ConA concanavalin A, MSC mesenchymal stem cell, PHA leucoagglutinin

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