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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Intraarterial transplantation of human umbilical cord blood mononuclear cells in hyperacute stroke improves vascular function

Fig. 3

a Representative cerebral blood flow (CBF), apparent diffusion coefficient (ADC), clusters of tissue, and T2 map of a PBS vehicle- and stem cell-treated animal at day 0 (30 min), and at 2, 14, and 28 days post-middle cerebral arterial occlusion (MCAO). Cluster analysis yielded ‘perfusion-diffusion mismatch’ (green), and ‘ischemic core’ (red) clusters, based on initial ADC and CBF data. Hypointense areas on the CBF and ADC map show the initial stroke lesion at day 0. Hyperintense areas on the T2 map indicate stroke lesion at the following time points. b Quantitative analysis of stroke lesion volume over the time course (n = 6 per group, mean ± SEM). *P < 0.05. c Percentage of rescued core and mismatch tissues were analyzed based on day 28 and day 0 MRI data (n = 6 per group, mean ± SEM). *P < 0.05, versus the PBS vehicle; ### P < 0.001, #### P < 0.0001, versus core tissue of the same group. hUCB human umbilical cord blood, MNC mononuclear cell, PBS phosphate-buffered saline

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