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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Distribution pattern following systemic mesenchymal stem cell injection depends on the age of the recipient and neuronal health

Fig. 1

Biodistribution of young and old MSCs transplanted into young, old, and APP/PS1 mice. MSCs derived from young or old male mice were transplanted into young, old, and Alzheimer’s disease female mice via tail-vein injections. Percentage of male gDNA in organs was assessed and quantified 28 days after transplantation. (a) Young MSCs were intravenously transplanted into either young (n = 3) or old (n = 4) recipient mice. Young MSCs were found in the lungs, axillary lymph nodes, blood, kidney, bone marrow, spleen, liver, heart, and brain cortex of mice. In contrast, young MSCs were only found in the brain cortex of old mice. (b) Aged MSCs were transplanted into young (n = 3) and old (n = 5) mice. Biodistribution of aged MSCs was exclusive to the blood and spleen. (c) Young MSCs were injected into the tail veins of APP/PS1 Alzheimer’s disease (AD) mice (n = 5). Biodistribution was found in the cortex, cerebellum, hippocampus, olfactory bulb, brain stem, liver, bone marrow, and lung. gDNA genomic DNA, MSC mesenchymal stem cell

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