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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: CK2.1, a bone morphogenetic protein receptor type Ia mimetic peptide, repairs cartilage in mice with destabilized medial meniscus

Fig. 4

DMM mice injected with PBS and HGP induced collagen type X expression in articular cartilage but HGP-CK2.1 did not. DMM mice injected with PBS or HGP-CK2.1 (6 μM) or HGP and sham-operated mice were immunostained for collagen type X (green), and Hoechst (blue) was used to determine the nucleus of the residing cell and location. Immunostaining demonstrates increased collagen type X expression in the AC of PBS- and HGP-injected mice but not HGP-CK2.1-injected mice. Scale bars = 100 μm. AC articular cartilage, HGP hydrogel particle, MF medial femur, MC marrow cavity, PBS phosphate-buffered saline, PC patellar cavity, SHAM sham-operated

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