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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: CK2.1, a bone morphogenetic protein receptor type Ia mimetic peptide, repairs cartilage in mice with destabilized medial meniscus

Fig. 5

DMM mice injected with PBS showed increased osteocalcin expression but not those injected with HGP-CK2.1. DMM mice injected with PBS or HGP-CK2.1 (6 μM) or HGP and sham-operated mice were immunostained for osteocalcin (green), and Hoechst (blue) was used to determine the nucleus of the residing cell and location. Immunostaining demonstrates increased osteocalcin expression in AC of PBS-injected mice but not HGP-CK2.1-injected mice. Scale bars = 100 μm. AC articular cartilage, HGP hydrogel particle, MF medial femur, MC marrow cavity, PBS phosphate-buffered saline, PC patellar cavity, SHAM sham-operated

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