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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Critical attributes of human early mesenchymal stromal cell-laden microcarrier constructs for improved chondrogenic differentiation

Fig. 6

heMSC-Cultispher-S constructs seeded with 50 microcarriers per construct with 70% cell confluency induced effective cell growth and chondrogenic differentiation. a Construct diameter and DNA content per construct. Dotted line indicates construct diameter attained by optimally defined heMSC-Cytodex 1 constructs after 28 days of differentiation. This diameter is obtained by heMSC-Cultispher-S constructs seeded with 50 microcarriers per construct (grey circle). b, c Glycosaminogycan (GAG) and Collagen II content per construct as well as GAG/DNA and Collagen II/DNA ratios. heMSC-Cultispher-S constructs seeded with 50 microcarriers (grey circle) significantly induced the highest GAG/DNA and Collagen II/DNA ratios at day 28 of differentiation when compared to constructs with different microcarrier numbers. p values: *p < 0.05

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Stem Cell Research & Therapy

ISSN: 1757-6512