Fig. 3
Leucocyte infiltration in colon cross sections. Sections of the guinea-pig distal colon were labelled with pan-leucocyte marker anti-CD45 to observe the effects of MSC treatments on leucocyte infiltration. CD45-IR leucocytes were visualized within the mucosa and muscular layers of distal colon sections from guinea-pigs collected at 72 hours post induction of colitis (a-e). Scale bars = 100 μm. The total number of CD45-IR cells per 1.5 mm2 area quantified in the mucosa (f) and muscular (g) layers of the colon cross sections. ### P < 0.001 when compared to sham-treated guinea-pigs, ***P < 0.001 when compared to TNBS-only administered guinea-pigs, ^^^P < 0.001 when compared to 1 × 105 MSC-treated guinea-pigs. n = 4/group/time point. IR immunoreactive, MSCs mesenchymal stem cells, TNBS 2,4,6-trinitrobenzene sulfonic acid