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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: The neuroprotective effects of human bone marrow mesenchymal stem cells are dose-dependent in TNBS colitis

Fig. 7

Effects of MSC treatments on ChAT-IR myenteric neurons. Excitatory myenteric neurons were identified by anti-ChAT antibody in whole-mount preparations of the distal colon from sham-treated, TNBS-only, 1 × 105 MSC-treated, 1 × 106 MSC-treated and 3 × 106 MSC-treated guinea-pigs (a-e). Scale bars = 100 μm. The total number of ChAT-IR neurons were counted per ganglion (average of ten ganglia) (f) and per 2 mm2 area (h) of the colon. The proportion of ChAT-IR neurons to Hu-IR neurons per ganglia (g) and per area (i). ## P < 0.01, ### P < 0.001 when compared to sham-treated guinea-pigs, **P < 0.01, ***P < 0.001 when compared to TNBS-only administered guinea-pigs, ^P < 0.05, ^^P < 0.01 when compared to 1 × 105 MSC-treated guinea-pigs. n = 4/group/time point. ChAT choline acetyltransferase, IR immunoreactive, MSCs mesenchymal stem cells, TNBS 2,4,6-trinitrobenzene sulfonic acid

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