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Table 2 Dose-dependent effects of MSC treatment on leucocyte infiltration, nerve fibre density and number of myenteric neurons in the inflamed distal colon

From: The neuroprotective effects of human bone marrow mesenchymal stem cells are dose-dependent in TNBS colitis

 

Sham

TNBS

TNBS + 1 × 105 MSCs

TNBS + 1 × 106 MSCs

TNBS + 3 × 106 MSCs

Total no. CD45-IR cells

 Mucosa

341 ± 34

927 ± 31###

686 ± 23***###

368 ± 27***^^^

425 ± 25***^^^

 Muscle

33 ± 4

131 ± 1###

83 ± 5***###

32 ± 6***^^^

29 ± 6***^^^

β-tubulin (III)-IR fibre density

 Mucosa

3.31 ± 0.09

1.68 ± 0.05###

2.54 ± 0.05***###

3.39 ± 0.08***^^^

3.35 ± 0.04***^^^

 Muscle

5.54 ± 0.17

4.03 ± 0.11###

3.93 ± 0.07###

5.67 ± 0.10***^^^

5.50 ± 0.12***^^^

Total no. of Hu-IR myenteric neurons

 Ganglia

124 ± 2

108 ± 5#

104 ± 2##

128 ± 3**^^

127 ± 4**^^

 Area

1498 ± 13

1330 ± 41##

1312 ± 20###

1510 ± 19***^^

1513 ± 12***^^^

Total no. of nNOS-IR myenteric neurons

 Ganglia

22 ± 1

27 ± 1##

27 ± 1###

20 ± 1***^^

22 ± 1**^^^

 Area

262 ± 12

318 ± 7###

317 ± 5###

277 ± 6**^^

246 ± 3***^^^

Proportion of nNOS-IR myenteric neurons

 Ganglia

17 ± 1

26 ± 2###

27 ± 1###

16 ± 1***^^^

18 ± 1***^^^

 Area

17 ± 1

24 ± 1###

24 ± 1###

18 ± 1***^^^

16 ± 1***^^^

Total no. of ChAT-IR myenteric neurons

 Ganglia

67 ± 1

52 ± 2##

57 ± 2##

64 ± 2**^

65 ± 3**^

 Area

749 ± 29

545 ± 24###

585 ± 23##

708 ± 29**^

743 ± 14***^^

Proportion of ChAT-IR myenteric neurons

 Ganglia

54 ± 1

49 ± 1

55 ± 1

50 ± 1

52 ± 4

 Area

50 ± 2

41 ± 1##

45 ± 2

47 ± 2*

49 ± 1*

  1. MSC mesenchymal stem cell, TNBS 2,4,6-trinitrobenzene sulfonic acid, IR immunoreactive, nNOS neuronal nitric oxide synthase, ChAT Choline acetyltransferase
  2. # P < 0.05, ## P < 0.01, ### P < 0.001 when compared to sham-treated guinea-pigs
  3. *P < 0.05, **P < 0.01, ***P < 0.001 when compared to TNBS-only administered guinea-pigs
  4. ^P < 0.05, ^^P < 0.01, ^^^P < 0.001 when compared to 1 × 105 MSC-treated guinea-pigs