| Sham | TNBS | TNBS + 1 × 105 MSCs | TNBS + 1 × 106 MSCs | TNBS + 3 × 106 MSCs |
---|---|---|---|---|---|
Total no. CD45-IR cells | |||||
 Mucosa | 341 ± 34 | 927 ± 31### | 686 ± 23***### | 368 ± 27***^^^ | 425 ± 25***^^^ |
 Muscle | 33 ± 4 | 131 ± 1### | 83 ± 5***### | 32 ± 6***^^^ | 29 ± 6***^^^ |
β-tubulin (III)-IR fibre density | |||||
 Mucosa | 3.31 ± 0.09 | 1.68 ± 0.05### | 2.54 ± 0.05***### | 3.39 ± 0.08***^^^ | 3.35 ± 0.04***^^^ |
 Muscle | 5.54 ± 0.17 | 4.03 ± 0.11### | 3.93 ± 0.07### | 5.67 ± 0.10***^^^ | 5.50 ± 0.12***^^^ |
Total no. of Hu-IR myenteric neurons | |||||
 Ganglia | 124 ± 2 | 108 ± 5# | 104 ± 2## | 128 ± 3**^^ | 127 ± 4**^^ |
 Area | 1498 ± 13 | 1330 ± 41## | 1312 ± 20### | 1510 ± 19***^^ | 1513 ± 12***^^^ |
Total no. of nNOS-IR myenteric neurons | |||||
 Ganglia | 22 ± 1 | 27 ± 1## | 27 ± 1### | 20 ± 1***^^ | 22 ± 1**^^^ |
 Area | 262 ± 12 | 318 ± 7### | 317 ± 5### | 277 ± 6**^^ | 246 ± 3***^^^ |
Proportion of nNOS-IR myenteric neurons | |||||
 Ganglia | 17 ± 1 | 26 ± 2### | 27 ± 1### | 16 ± 1***^^^ | 18 ± 1***^^^ |
 Area | 17 ± 1 | 24 ± 1### | 24 ± 1### | 18 ± 1***^^^ | 16 ± 1***^^^ |
Total no. of ChAT-IR myenteric neurons | |||||
 Ganglia | 67 ± 1 | 52 ± 2## | 57 ± 2## | 64 ± 2**^ | 65 ± 3**^ |
 Area | 749 ± 29 | 545 ± 24### | 585 ± 23## | 708 ± 29**^ | 743 ± 14***^^ |
Proportion of ChAT-IR myenteric neurons | |||||
 Ganglia | 54 ± 1 | 49 ± 1 | 55 ± 1 | 50 ± 1 | 52 ± 4 |
 Area | 50 ± 2 | 41 ± 1## | 45 ± 2 | 47 ± 2* | 49 ± 1* |