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Table 3 Different expression of genes at the 4-week follow-up in control patients and in stem cell treated patients compared to baseline

From: Autologous bone marrow-derived cell transplantation in decompensated alcoholic liver disease: what is the impact on liver histology and gene expression patterns?

Accession number

Gene name

Control patients

SCT patients

Affymetrix fold-expression

p value

Nanostring fold-expression

p value

Affymetrix fold-expression

p value

Nanostring fold-expression

p value

Macrophages, inflammation and chemotaxis

 NM_001040059, NM_001251

CD68

CD68 molecule

–1.16

0.0740

–1.65

0.3234

–1.13

0.1404

1.00

0.9935

 NM_001130046, NM_004591

CCL20 (chemokine (C-C motif) ligand 20)

–1.78

0.0234

–2.26

0.0032

 NM_003955

SOCS3 (suppressor of cytokine signaling 3)

–1.30

0.1987

–6.5

0.0574

–1.96

0.0033

–28.96

0.0017

 NM_002228

JUN (jun proto-oncogene)

–1.65

0.0212

–2.07

0.0021

 NM_004887

CXCL14 (chemokine (C-X-C motif) ligand 14)

–1.07

0.7539

–1.39

0.6367

–1.70

0.0278

–8.48

0.0057

 NM_001100812, NM_022059

CXCL16 (chemokine (C-X-C motif) ligand 16)

–1.18

0.0351

6.37

0.0355

–1.19

0.0342

–16.20

0.0029

Liver regeneration, cell cycle and stem cells

 NM_000601, NM_001010931, NM_001010932, NM_001010933, NM_001010934

HGF (Hepatocyte growth factor)

–1.20

0.0529

3.40

0.0144

–1.17

0.1073

–1.32

0.5506

 NM_001528.2

HGFAC (Hepatocyte growth factor activator)

1.10

0.4267

1.34

0.0267

 NM_001170406, NM_001170407, NM_001786, NM_033379

CDK1 (cyclin-dependent kinase 1)

–1.20

0.3340

–1.19

0.7497

–1.25

0.2553

–1.31

0.6225

 NM_031966

CCNB1 (Cyclin B1)

–1.21

0.2251

–2.17

0.2864

–1.38

0.0558

–2.22

0.2748

 NM_001255

CDC20 (cell division cycle 20 homolog)

–1.03

0.8235

–1.45

0.5416

–1.18

0.2489

–1.32

0.6487

 NM_005556

CK7 (keratin 7)

1.08

0.6855

–2.48

0.3612

–1.20

0.3464

–12.28

0.0178

 NM_002276

CK19 (keratin 19)

–1.16

0.4008

–2.33

0.3545

–1.38

0.0900

–13.09

0.0092

 NM_002838, NM_080921, NM_080923

PTPRC (CD45) (protein tyrosine phosphatase, receptor type, C)

–1.53

0.0098

–3.61

0.06

–1.04

0.8147

–1.32

0.675

 NM_003122

SPINK1 (serine peptidase inhibitor, Kazal type 1)

–2.42

0.0591

–6.19

0.1449

–1.07

0.8789

–1.28

0.8391

 NM_016639

TNFRSF12A (tumor necrosis factor receptor superfamily, member 12A)

–2.02

0.0003

–11.26

0.0207

–1.75

0.0016

–31.33

0.0019

Fibrosis

 NM_000088

COL1A1 (collagen, type I, alpha 1)

–1.96

0.0001

–5.41

0.0181

–1.47

0.0137

–1.34

0.6628

 NM_000089

COL1A2 (collagen, type I, alpha 2)

–2.26

0.0001

–2.17

0.0216

–1.61

0.0136

–1.53

0.1871

Metabolism/function

 NM_145740

GSTA1 (glutathione S-transferase alpha 1)

2.10

0.0258

2.51

0.1955

2.12

0.0296

7.85

0.007

 NM_000846

GSTA2 (glutathione S-transferase alpha 1)

1.87

0.0573

2.72

0.0183

 NM_000780.3

CYP7A1 (cytochrome P450, family 7, subfamily A, polypeptide 1)

2.72

0.0183

2.59

0.0193

 NM_000761

CYP1A2 (cytochrome P450, family 1, subfamily A, polypeptide 2)

2.15

0.0073

2.24

0.0067

 NM_001195728, NM_004171

SLC1A2 (solute carrier family 1 (glial high affinity glutamate transporter), member 2)

1.38

0.064

–1.09

0.4444

 NM_005577

LPA (lipoprotein, Lp(a))

2.18

0.0070

27.09

0.0021

2.39

0.0041

20.77

0.0041

 NM_000482

APOA4 (apolipoprotein A-IV)

–4.56

0.0001

–17.89

0.0053

–5.97

0.0000

–126.73

0.00001

 NM_020299

AKR1B10 (aldo-keto reductase family 1, member B10 (aldose reductase))

–1.85

0.0115

–1.61

0.0302

–2.23

0.0024

–2.33

0.0005

 NM_001444, NR_002935

FABP5/FABP5P3 (fatty acid binding protein 5 (psoriasis-associated)/fatty acid binding protein 5 pseudogene 3)

–1.65

0.0212

–2.07

0.0021

 NM_005764

PDZK1 (PDZK1 interacting protein 1)

–1.49

0.0972

–5.82

0.0655

–1.73

0.0330

–12.02

0.0124

 NM_000636, NM_001024465, NM_001024466

SOD2 (superoxide dismutase 2, mitochondrial)

–1.57

0.0193

–1.21

0.2164

–1.61

0.0187

–1.44

0.0267

  1. Values shown in bold are significant at p < 0.05