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Table 3 Different expression of genes at the 4-week follow-up in control patients and in stem cell treated patients compared to baseline

From: Autologous bone marrow-derived cell transplantation in decompensated alcoholic liver disease: what is the impact on liver histology and gene expression patterns?

Accession number Gene name Control patients SCT patients
Affymetrix fold-expression p value Nanostring fold-expression p value Affymetrix fold-expression p value Nanostring fold-expression p value
Macrophages, inflammation and chemotaxis
 NM_001040059, NM_001251 CD68
CD68 molecule
–1.16 0.0740 –1.65 0.3234 –1.13 0.1404 1.00 0.9935
 NM_001130046, NM_004591 CCL20 (chemokine (C-C motif) ligand 20) –1.78 0.0234 –2.26 0.0032
 NM_003955 SOCS3 (suppressor of cytokine signaling 3) –1.30 0.1987 –6.5 0.0574 –1.96 0.0033 –28.96 0.0017
 NM_002228 JUN (jun proto-oncogene) –1.65 0.0212 –2.07 0.0021
 NM_004887 CXCL14 (chemokine (C-X-C motif) ligand 14) –1.07 0.7539 –1.39 0.6367 –1.70 0.0278 –8.48 0.0057
 NM_001100812, NM_022059 CXCL16 (chemokine (C-X-C motif) ligand 16) –1.18 0.0351 6.37 0.0355 –1.19 0.0342 –16.20 0.0029
Liver regeneration, cell cycle and stem cells
 NM_000601, NM_001010931, NM_001010932, NM_001010933, NM_001010934 HGF (Hepatocyte growth factor) –1.20 0.0529 3.40 0.0144 –1.17 0.1073 –1.32 0.5506
 NM_001528.2 HGFAC (Hepatocyte growth factor activator) 1.10 0.4267 1.34 0.0267
 NM_001170406, NM_001170407, NM_001786, NM_033379 CDK1 (cyclin-dependent kinase 1) –1.20 0.3340 –1.19 0.7497 –1.25 0.2553 –1.31 0.6225
 NM_031966 CCNB1 (Cyclin B1) –1.21 0.2251 –2.17 0.2864 –1.38 0.0558 –2.22 0.2748
 NM_001255 CDC20 (cell division cycle 20 homolog) –1.03 0.8235 –1.45 0.5416 –1.18 0.2489 –1.32 0.6487
 NM_005556 CK7 (keratin 7) 1.08 0.6855 –2.48 0.3612 –1.20 0.3464 –12.28 0.0178
 NM_002276 CK19 (keratin 19) –1.16 0.4008 –2.33 0.3545 –1.38 0.0900 –13.09 0.0092
 NM_002838, NM_080921, NM_080923 PTPRC (CD45) (protein tyrosine phosphatase, receptor type, C) –1.53 0.0098 –3.61 0.06 –1.04 0.8147 –1.32 0.675
 NM_003122 SPINK1 (serine peptidase inhibitor, Kazal type 1) –2.42 0.0591 –6.19 0.1449 –1.07 0.8789 –1.28 0.8391
 NM_016639 TNFRSF12A (tumor necrosis factor receptor superfamily, member 12A) –2.02 0.0003 –11.26 0.0207 –1.75 0.0016 –31.33 0.0019
Fibrosis
 NM_000088 COL1A1 (collagen, type I, alpha 1) –1.96 0.0001 –5.41 0.0181 –1.47 0.0137 –1.34 0.6628
 NM_000089 COL1A2 (collagen, type I, alpha 2) –2.26 0.0001 –2.17 0.0216 –1.61 0.0136 –1.53 0.1871
Metabolism/function
 NM_145740 GSTA1 (glutathione S-transferase alpha 1) 2.10 0.0258 2.51 0.1955 2.12 0.0296 7.85 0.007
 NM_000846 GSTA2 (glutathione S-transferase alpha 1) 1.87 0.0573 2.72 0.0183
 NM_000780.3 CYP7A1 (cytochrome P450, family 7, subfamily A, polypeptide 1) 2.72 0.0183 2.59 0.0193
 NM_000761 CYP1A2 (cytochrome P450, family 1, subfamily A, polypeptide 2) 2.15 0.0073 2.24 0.0067
 NM_001195728, NM_004171 SLC1A2 (solute carrier family 1 (glial high affinity glutamate transporter), member 2) 1.38 0.064 –1.09 0.4444
 NM_005577 LPA (lipoprotein, Lp(a)) 2.18 0.0070 27.09 0.0021 2.39 0.0041 20.77 0.0041
 NM_000482 APOA4 (apolipoprotein A-IV) –4.56 0.0001 –17.89 0.0053 –5.97 0.0000 –126.73 0.00001
 NM_020299 AKR1B10 (aldo-keto reductase family 1, member B10 (aldose reductase)) –1.85 0.0115 –1.61 0.0302 –2.23 0.0024 –2.33 0.0005
 NM_001444, NR_002935 FABP5/FABP5P3 (fatty acid binding protein 5 (psoriasis-associated)/fatty acid binding protein 5 pseudogene 3) –1.65 0.0212 –2.07 0.0021
 NM_005764 PDZK1 (PDZK1 interacting protein 1) –1.49 0.0972 –5.82 0.0655 –1.73 0.0330 –12.02 0.0124
 NM_000636, NM_001024465, NM_001024466 SOD2 (superoxide dismutase 2, mitochondrial) –1.57 0.0193 –1.21 0.2164 –1.61 0.0187 –1.44 0.0267
  1. Values shown in bold are significant at p < 0.05