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Table 1 Clinical characteristics of type 1 diabetic patients before and after insulin and AHSCT treatments

From: Immune response after autologous hematopoietic stem cell transplantation in type 1 diabetes mellitus

 

Insulin-only group

AHSCT group

Insulin-0M

Insulin-12M

AHSCT-0M

AHSCT-12M

Age (years)

20.18 ± 4.02

18.86 ± 1.46

Gender (female/male)

6/4

5/3

BMI (kg/cm2)

18.28 ± 1.39

19.25 ± 1.11

FBG (mmol/L)

6.50 ± 2.01

6.04 ± 1.70

6.26 ± 0.67

5.59 ± 1.40

HbA1c (%)

(mmol/mol)a

12.20 ± 3.50

(109.90 ± 38.42)

7.33 ± 1.42++

(56.63 ± 15.45)

11.49 ± 1.46

(102.00 ± 16.06)

6.80 ± 0.60###

(51.00 ± 6.73)

Anti-GAD (units/ml)

1230.38 (669.43–1957.29)

1200.00 (725.41–1980.02)

943.68 (294.69–2085.04)

150.4* (31.83–1315.52)

Insulin dose (U/kg/day)

0.66 ± 0.30

0.52 ± 0.34

0.61 ± 0.27

0.15 ± 0.15**###

Fasting C-peptide (ng/ml)

0.62 ± 0.25

0.60 ± 0.50

0.71 ± 0.30

1.01 ± 0.23*#

AUCC

4.56 ± 2.50

4.76 ± 1.42

5.93 ± 2.54

9.59 ± 2.98**#

  1. Data presented as mean ± SD or median (95% CI)
  2. AHSCT autologous hematopoietic stem cell transplantation, 0 M at baseline, 12 M at 12 months
  3. # P < 0.05, ### P < 0.001, compared with the AHSCT-0M group
  4. ++ P < 0.01, compared with the Insulin-0M group
  5. *P < 0.05, **P < 0.01, compared with the Insulin-12M group
  6. aHbA1c values were calculated as mmol/mol. The NGSP converter is available online (http://www.ngsp.org/convert1.asp)